Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

SE John; NL Opie; YT Wong; GS Rind; SM Ronayne; G Gerboni; SH Bauquier; TJ O'Brien; CN May; DB Grayden; TJ Oxley

Journal article

Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable

SE John, NL Opie, YT Wong, GS Rind, SM Ronayne, G Gerboni, SH Bauquier, TJ O'Brien, CN May, DB Grayden, TJ Oxley

Scientific Reports | NATURE PORTFOLIO | Published : 2018

DOI: 10.1038/s41598-018-26457-7

Download PDF

Abstract

Recent work has demonstrated the feasibility of minimally-invasive implantation of electrodes into a cortical blood vessel. However, the effect of the dura and blood vessel on recording signal quality is not understood and may be a critical factor impacting implementation of a closed-loop endovascular neuromodulation system. The present work compares the performance and recording signal quality of a minimally-invasive endovascular neural interface with conventional subdural and epidural interfaces. We compared bandwidth, signal-to-noise ratio, and spatial resolution of recorded cortical signals using subdural, epidural and endovascular arrays four weeks after implantation in sheep. We show t..

View full abstract

University of Melbourne Researchers

Sam John Author

Nicholas Opie Author

Gil Rind Author

Stephen Ronayne Author

Related Projects (8)

MINIMALLY-INVASIVE BRAIN MACHINE INTERFACE FOR ROBOTIC LIMB CONTROL

Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces (BMI..

MINIMALLY INVASIVE BRAIN CONTROLLED COMMUNICATION AND NAVIGATION

CONTROL OF PROSTHETIC LIMBS FROM DECODED BRAIN SIGNALS

This research will restore mobility to patients who suffer from paralysis. We aim to create a device, known as a brain-machine interface, wh..

Ian Potter Foundation Travel Grant

MINIMALLY INVASIVE ENDOVASCULAR NEURAL STIMULATION

Neural deficits such as Parkinson’s disease can be helped by electrically stimulating the brain to activate neurons. Current implants requir..

TARGETING THERAPEUTIC STIMULATION USING MINIMALLY INVASIVE NEUROMODULATION

MINIMALLY-INVASIVE BRAIN MACHINE INTERFACE FOR ROBOTIC LIMB CONTROL

Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces (BMI..

SAFETY AND EFFICACY VALIDATION OF THE STENTRODE: TRANSLATION OF A NOVEL BRAIN-MACHINE-INTERFACE INTO CLINICAL APPLICATION

PUBLIC ABSTRACT At present, there is no cure for the millions of people worldwide paralyzed by spinal cord injury. For many of these peopl..

Grants

Awarded by Office of Naval Research

Funding Acknowledgements

We thank Covidien (Medtronic) for provision of 30 Solitaire stentriever devices as a product research grant. T. Dornum, A. McDonald and T. Vale for surgical and animal handling assistance. We also acknowledge Prof. A. Burkitt, Mr. A. Meltzer, Mr. Stefan Wilson, and Mr. T. Scordas for their support and input. This work was funded by the National Health and Medical Research Council of Australia (NHMRC) Project Grant APP1062532, US Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office contract N66001-12-1- 4045; Office of Naval Research (ONR) lobal N62909-14-1-N020; Defence Health Foundation, Australia (Booster Grant); and the Victorian Government's Operational Infrastructure Support Program.